Butler, M.; Winstanley, S.; van Heel, D.; Lombardi, G.; Lechler, R.; Playford, R.; Ghosh, S.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA64
Academic Journal
The article cites a study on the expression of NOD2 by intestinal epithelial cells in an in vitro M cell model. NOD2 is a cytosolic detector of peptidoglycans-specifically muramyl dipeptides (MDP)—and is principally expressed by cells of the myeloid lineage (monocytes, macrophages and dendritic cells). NOD2 mutations are associated with about 20 percent of Crohn's disease cases, suggesting that recognition of bacterial MDP via NOD2 is an important sensory pathway in gut immunity. The study investigates the possibility that NOD2 is expressed by intestinal epithelial cells expressing characteristics of endocytic M cells.


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