Goede, A. C.; Sales, K. M.; Khan, K.; Caplin, M. E.; Winslet, M. C.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA64
Academic Journal
The article presents a study of pharmacological manipulation of angiotensin II and transforming growth factor (TGF) β-1 in mesothelial cells. Desmoplasia, peritoneal fibrosis and adhesion formation as seen in carcinoid tumours involve several cellular and humoral pathways. TGF β-1 is increased at the site of adhesions and in peritoneal effluent from CAPD patients with peritonecil fibrosis. The local renin angiotensin system (RAS) has been shown to modulate TGFβ-1 expression. The aim was to establish if an active local RAS exists in the peritoneum which may regulate TGF β-1 and hence fibrosis.


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