TITLE

IDENTIFICATION OF DIFFERENTIALLY EXPRESSED GENES FOLLOWING BACTERIAL ENTEROTOXIN INDUCED NEURONAL GROWTH AND DIFFERNTIATION IN PC12 CELLS

AUTHOR(S)
Casbum-Jones, A. C.; Young, C.; Herzyk, P.; Riboldi-Tunnicliffe, G.; Farthing, M. J. G.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA64
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article presents a study of the identification of differentially expressed genes following bacterial enterotoxin induced neuronal growth and differentiation in PC 12 cells. Cholera toxin (CT), Escherichia coli heat labile (LT), and heat stable (ST) toxins mediate intestinal secretion in part through an enteric reflex arc, this may be via a direct effect on enteric nerves. In PC 12 cells, CT and LT induce upregulation in genes involved in neuronal differentiation. A synergistic effect of CT or LT with NGF occurs in some NGF induced genes, supporting the phenotypic synergistic changes previously observed. New gene upregulation occurs when PC 12 cells are exposed to CT or LT with NGF. These findings suggest that CT, LT, and NGF have separate but synergistic effects on gene expression.
ACCESSION #
13219062

 

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