Bromfield, A.; Ogunbiyi, O.; Keshav, S.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA64
Academic Journal
The article presents a study on the secretory response of human Paneth cells to bacterial antigens. Paneth cells are specialized epithelial cells located at the base of the crypts of Leiberkuhn where they release secretory granules apically into the intestinal lumen. Paneth cell granules contain several important anti-microbial peptides, including lysozyme, secretory phospholipase A2 and defensins which are critically important in host immunity, especially against bacteria in the gut. Cholinergic stimulation of Paneth cell degranulation is well known, as well as secretion of microbial defensins by murine Paneth cells in response to bacteria.


Related Articles

  • Paneth cell α-defensins: peptide mediators of innate immunity in the small intestine. Ouellette, Andre // Springer Seminars in Immunopathology;Sep2005, Vol. 27 Issue 2, p133 

    Epithelial cells contribute to innate immunity by releasing antimicrobial peptides (AMPs) onto mucosal surfaces. In the small bowel, Paneth cells at the base of the crypts of Lieberkühn secrete α-defensins and additional AMPs at high levels in response to cholinergic stimulation and when...

  • Intracellular potentiation between two second messenger systems may contribute to cholera toxin induced intestinal secretion in humans. Banks M R; Golder M; Farthing M J G; Burleigh D E // Gut;Jan2004, Vol. 53 Issue 1, p50 

    BACKGROUND: Cholera toxin (CT) acts on intestinal epithelial cells both directly and indirectly via activation of a secretory neural reflex. The reflex may release acetylcholine as one of its final neurotransmitters. This opens up the possibility of a third mechanism of action for CT, namely a...

  • The role of neutrophils during intestinal inflammation. Fournier, B M; Parkos, C A // Mucosal Immunology (1933-0219);Jul2012, Vol. 5 Issue 4, p354 

    Polymorphonuclear leukocytes or neutrophils play a critical role in the maintenance of intestinal homeostasis. They have elegant defense mechanisms to eliminate microbes that have translocated across a single layer of mucosal epithelial cells that form a critical barrier between the gut lumen...

  • Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis. Bevins, Charles L.; Salzman, Nita H. // Nature Reviews Microbiology;May2011, Vol. 9 Issue 5, p356 

    Building and maintaining a homeostatic relationship between a host and its colonizing microbiota entails ongoing complex interactions between the host and the microorganisms. The mucosal immune system, including epithelial cells, plays an essential part in negotiating this equilibrium. Paneth...

  • Food-Derived Peptides and Intestinal Functions. Shimizu, Makoto; Dong Ok Son // Current Pharmaceutical Design;Mar2007, Vol. 13 Issue 9, p885 

    The intestines are an important organ responsible for nutrient absorption, metabolism and recognition of food signals. The organ also acts as a physical and biological barrier against harmful substances including food pathogens and environmental chemicals. Food-derived peptides with a variety of...

  • Milk fermentation products of L. helveticus R389 activate calcineurin as a signal to promote gut mucosal immunity. Vinderola, Gabriel; Matar, Chantal; Perdigón, Gabriela // BMC Immunology;2007, Vol. 8, p1 

    Background: Fermented milks containing probiotic bacteria are a way of delivering bioactive constituents to targets in the gastrointestinal tract. We reported previously that the fermentation of milk at constant pH 6 by L. helveticus R389 increased its content of peptide fractions, and the oral...

  • Protection of epithelial cells from Salmonella enterica serovar Enteritidis invasion by antibodies against the SPI-1 type III secretion system. Desin, Taseen S.; Mickael, Claudia S.; Lam, Po-King S.; Potter, Andrew A.; Köster, Wolfgang // Canadian Journal of Microbiology;Jun2010, Vol. 56 Issue 6, p522 

    Salmonella enterica serovar Enteritidis (Salmonella Enteritidis) is one of the major causes of bacterial food-borne illness in humans. During the course of infection, Salmonella Enteritidis uses 2 type III secretion systems (T3SS), one of which is encoded on Salmonella pathogenicity island 1...

  • Loss of Sonic Hedgehog Leads to Alterations in Intestinal Secretory Cell Maturation and Autophagy. Gagné-Sansfaçon, Jessica; Allaire, Joannie M.; Jones, Christine; Boudreau, François; Perreault, Nathalie // PLoS ONE;Jun2014, Vol. 9 Issue 6, p1 

    Background: Intestinal epithelial cells express the Sonic and Indian hedgehog ligands. Despite the strong interest in gut hedgehog signaling in GI diseases, no studies have specifically addressed the singular role of intestinal epithelial cell Sonic hedgehog signaling. The aim of this study was...

  • A sweet attachment. Amoils, Shannon // Nature Reviews Microbiology;Feb2006, Vol. 4 Issue 2, p84 

    The article focuses on the study regarding the use of Vibrio cholerae, a pathogenic bacterium, to colonize contrasting environments such human small intestines and environmental water sources. A panel of V. cholerae has been screened for defective epithelial-cell attachment to identify proteins...


Read the Article


Sign out of this library

Other Topics