Bromfield, A.; Ogunbiyi, O.; Keshav, S.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA64
Academic Journal
The article presents a study on the secretory response of human Paneth cells to bacterial antigens. Paneth cells are specialized epithelial cells located at the base of the crypts of Leiberkuhn where they release secretory granules apically into the intestinal lumen. Paneth cell granules contain several important anti-microbial peptides, including lysozyme, secretory phospholipase A2 and defensins which are critically important in host immunity, especially against bacteria in the gut. Cholinergic stimulation of Paneth cell degranulation is well known, as well as secretion of microbial defensins by murine Paneth cells in response to bacteria.


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