Newsome, P. N.; Dalakos, E.; Hayes, P. C.; Harrison, D. J.; Plevris, J. N.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA63
Academic Journal
The article presents a study stating that serum from patients with acute liver failure decreases T cell differentiation of human stem cells. Previous studies have shown that CD34 stem cells are mobilised in response to certain types of human liver injury, and that ability to mobilise such cells is associated with an improved clinical outcome. However the effect of human liver injury serum on isolated human stem cells in terms of necrosis and differentiation profile (hepatocytic and haematopoietic) is poorly understood.


Related Articles

  • Therapeutic potential of transplanted placental mesenchymal stem cells in treating Chinese miniature pigs with acute liver failure.  // BMC Medicine;2012, Vol. 10 Issue 1, p56 

    The article focuses on a study, which aims to isolate mesenchymal stem cells from human placenta (hPMSCs) and identify their therapeutic potential to treat Chinese experimental miniature pigs with acute liver failure (ALF). Before being employed as the donor cells for transplantation, hPMSCs...

  • Stem Cells Can Convert to Liver Tissue, Help Restore Damaged Organ.  // Ascribe Newswire: Medicine;6/1/2004, p172 

    Bone marrow stem cells, when exposed to damaged liver tissue, can quickly convert into healthy liver cells and help repair the damaged organ, according to new research from the Johns Hopkins Kimmel Cancer Center. Researchers also observed that stem cells transplanted into mice with liver...

  • Transcriptional Regulation of Lineage Commitment - A Stochastic Model of Cell Fate Decisions. Teles, Jose; Pina, Cristina; Edén, Patrik; Ohlsson, Mattias; Enver, Tariq; Peterson, Carsten // PLoS Computational Biology;Aug2013, Vol. 9 Issue 8, p1 

    Molecular mechanisms employed by individual multipotent cells at the point of lineage commitment remain largely uncharacterized. Current paradigms span from instructive to noise-driven mechanisms. Of considerable interest is also whether commitment involves a limited set of genes or the entire...

  • The subtype CD200-positive, chorionic mesenchymal stem cells from the placenta promote regeneration of human hepatocytes. Wang, Jian; Zhu, Zhengyan; Huang, Yong; Wang, Peng; Luo, Ying; Gao, Yingtang; Du, Zhi // Biotechnology Letters;Jun2014, Vol. 36 Issue 6, p1335 

    Human placental mesenchymal stem cells (hPMSCs), for the treatment of fulminant hepatic failure, have been widely studied. Only a few studies have investigated the effect of the subtype CD200hPMSCs on regeneration of human hepatocytes. CD200hPMSCs can down-regulate activity of several...

  • Elevations of tumor necrosis factor receptor 1 at day 7 and acute graft-versus-host disease after allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning. Willems, E; Humblet-Baron, S; Dengis, O; Seidel, L; Beguin, Y; Baron, F // Bone Marrow Transplantation;Sep2010, Vol. 45 Issue 9, p1442 

    Acute GVHD has remained a significant cause of nonrelapse mortality after allogeneic hematopoietic cell transplantation (HCT) with nonmyeloablative conditioning. The role of TNF-α in the biology of acute GVHD after nonmyeloablative conditioning has not been studied thus far. Here, we measured...

  • Hepatocytes from non-hepatic adult stem cells.  // Nature;7/20/2000, Vol. 406 Issue 6793, p257 

    Reports on a study of stem cells and how hepatocytes may develop from them. Background on stem cells and their rounds of diversion; Details of experiments conducted on mice and humans; How stem cells may mobilize during liver failure to increase the regenerative capacity of the liver.

  • Reversal of mouse hepatic failure using an implanted liver-assist device containing ES cell–derived hepatocytes. Soto-Gutiérrez, Alejandro; Kobayashi, Naoya; Rivas-Carrillo, Jorge David; Navarro-Álvarez, Nalu; Debaio Zhao; Okitsu, Teru; Noguchi, Hirofumi; Basma, Hesham; Tabata, Yashuhiko; Yong Chen; Tanaka, Kimiaki; Narushima, Michiki; Miki, Atsushi; Ueda, Tadayoshi; Hee-Sook Jun; Ji-Won Yoon; Lebkowski, Jane; Tanaka, Noriaki; Fox, Ira J. // Nature Biotechnology;Nov2006, Vol. 24 Issue 11, p1412 

    Severe acute liver failure, even when transient, must be treated by transplantation and lifelong immune suppression. Treatment could be improved by bioartificial liver (BAL) support, but this approach is hindered by a shortage of human hepatocytes. To generate an alternative source of cells for...

  • Transplantation of allogeneic CD34-selected peripheral stem cells does not prevent transmission of hepatitis C virus from an infected donor. Tomás, J F; Rodriguez-Iñigo, E; Bartolomé, J; Alegre, A; Fernández-Rañada, J M; Carreño, V // Bone Marrow Transplantation;7/1/99, Vol. 24 Issue 1, p109 

    There is little information on the clinical course of transplantation from HCV-positive donors. However, it seems that there is no increased risk of acute liver failure after the procedure and that the presence of HCV-RNA in serum is necessary for transmission to take place. We report a case of...

  • Cytokine receptors and hematopoietic differentiation. Robb, L. // Oncogene;10/15/2007, Vol. 26 Issue 47, p6715 

    Colony-stimulating factors and other cytokines signal via their cognate receptors to regulate hematopoiesis. In many developmental systems, inductive signalling determines cell fate and, by analogy with this, it has been postulated that cytokines, signalling via their cognate receptors, may play...


Read the Article


Sign out of this library

Other Topics