TITLE

SERUM FROM PATIENTS WITH ACUTE LIVER FAILURE DECREASES T CELL DIFFERENTIATION OF HUMAN STEM CELLS

AUTHOR(S)
Newsome, P. N.; Dalakos, E.; Hayes, P. C.; Harrison, D. J.; Plevris, J. N.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA63
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article presents a study stating that serum from patients with acute liver failure decreases T cell differentiation of human stem cells. Previous studies have shown that CD34 stem cells are mobilised in response to certain types of human liver injury, and that ability to mobilise such cells is associated with an improved clinical outcome. However the effect of human liver injury serum on isolated human stem cells in terms of necrosis and differentiation profile (hepatocytic and haematopoietic) is poorly understood.
ACCESSION #
13219060

 

Related Articles

  • Role of liver progenitors in acute liver injury. Best, Jan; Dollé, Laurent; Manka, Paul; Coombes, Jason; van Grunsven, Leo A.; Wing-Kin Syn // Frontiers in Physiology;Sep2013, Vol. 4, p1 

    Acute liver failure (ALF) results from the acute and rapid loss of hepatocyte function and frequently exhibits a fulminant course, characterized by high mortality in the absence of immediate state-of-the-art intensive care and/or emergency liver transplantation (ELT). The role of...

  • The Role of Interferon-γ Inducible Protein-10 in a Mouse Model of Acute Liver Injury Post Induced Pluripotent Stem Cells Transplantation. Che-Chang Chan; Ling-Yi Cheng; Jean Lu; Yi-Hsiang Huang; Shih-Hwa Chiou; Ping-Hsing Tsai; Teh-Ia Huo; Han-Chieh Lin; Fa-Yauh Lee // PLoS ONE;Dec2012, Vol. 7 Issue 12, p1 

    Background: Liver injuries are important medical problems that require effective therapy. Stem cell or hepatocyte transplantation has the potential to restore function of the damaged liver and ameliorate injury. However, the regulatory factors crucial for the repair and regeneration after cell...

  • SDF-1/CXCR4 Axis Promotes MSCs to Repair Liver Injury Partially through Trans-Differentiation and Fusion with Hepatocytes. Hao, Ning-Bo; Li, Chang-Zhu; Lü, Mu-Han; Tang, Bo; Wang, Su-Min; Wu, Yu-Yun; Liang, Guang-Ping; Yang, Shi-Ming // Stem Cells International;8/2/2015, Vol. 2015, p1 

    MSCs have become a popular target for developing end-stage liver therapies. In this study, two models of bone marrow chimeric mice were used to construct the liver failure models. Then it was found that MSCs can transdifferentiate into hepatocyte-like cells and these hepatocyte-like cells can...

  • Therapeutic potential of transplanted placental mesenchymal stem cells in treating Chinese miniature pigs with acute liver failure.  // BMC Medicine;2012, Vol. 10 Issue 1, p56 

    The article focuses on a study, which aims to isolate mesenchymal stem cells from human placenta (hPMSCs) and identify their therapeutic potential to treat Chinese experimental miniature pigs with acute liver failure (ALF). Before being employed as the donor cells for transplantation, hPMSCs...

  • Differentiation and Transplantation of Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells. Asgari, Samira; Moslem, Mohsen; Bagheri-Lankarani, Kamran; Pournasr, Behshad; Miryounesi, Maryam; Baharvand, Hossein // Stem Cell Reviews & Reports;Aug2013, Vol. 9 Issue 4, p493 

    The generation of human induced pluripotent stem cells (hiPSCs) with a high differentiation potential provided a new source for hepatocyte generation not only for drug discovery and in vitro disease models, but also for cell replacement therapy. However, the reported hiPSC-derived...

  • Stem Cells Can Convert to Liver Tissue, Help Restore Damaged Organ.  // Ascribe Newswire: Medicine;6/1/2004, p172 

    Bone marrow stem cells, when exposed to damaged liver tissue, can quickly convert into healthy liver cells and help repair the damaged organ, according to new research from the Johns Hopkins Kimmel Cancer Center. Researchers also observed that stem cells transplanted into mice with liver...

  • Alchemy in the liver: fact or fusion? Daley, George Q // Nature Medicine;Jul2004, Vol. 10 Issue 7, p671 

    Focuses on the hypothesis that hematopoietic stem cells (HSCs) might be intrinsically plastic and, through transdifferentiation, able to repair damaged tissues throughout the body. Examinations of this hypothesis that prove that donor cells have simply fused with resident host tissue cells after...

  • Activation of stem cells in hepatic diseases. Bird, T. G.; Lorenzini, S.; Forbes, S. J. // Cell & Tissue Research;Dec2007, Vol. 331 Issue 1, p283 

    The liver has enormous regenerative capacity. Following acute liver injury, hepatocyte division regenerates the parenchyma but, if this capacity is overwhelmed during massive or chronic liver injury, the intrinsic hepatic progenitor cells (HPCs) termed oval cells are activated. These HPCs are...

  • Stem Cell Factor Attenuates Liver Damage in a Murine Model of Acetaminophen-Induced Hepatic Injury. Simpson, Kenneth; Hogaboam, Cow M.; Kunkel, Steven L.; Harrison, David J.; Bone-Larson, Cindy; Lukacs, Nicholas W. // Laboratory Investigation (00236837);Feb2003, Vol. 83 Issue 2, p199 

    Acute liver injury is a common cause of intensive care unit visits. In these studies, we used a murine model of acetaminophen poisoning to examine the role of stem cell factor (SCF) on liver damage. In the initial studies, we identified that the liver produces relatively high constitutive levels...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics