Manzo, B. A.; Sanderson, I. R.; Wilson, J. W.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA63
Academic Journal
The article presents a study stating that Helicobacter pylori express an E2A homologue. It has been shown earlier that Helicobacter pylori can regulate acutely the expression of Id helix-loop-helix transcriptional regulators, at both mRNA and protein level. Specifically, Id-1 and ld-3 were down regulated two to 24 hours after exposure of gastric epithelial cells to H pylori. Consequently, it was hypothesised that the transcriptional activity of their ubiquitously expressed partner protein, E2A, would be increased. Western blotting demonstrated two immunoreactive bands in untreated AGS gastric epithelial cells, corresponding to the molecular sizes of E47 and E12, the products of the two E2A splice variants.


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