TITLE

VITAMIN C INHIBITS NUCLEAR FACTOR-κB (NF-κB) ACTIVATION IN OESOPHAGEAL CELLS EXPOSED TO DEOXYCHOLIC ACID--POTENTIAL CANCER PREVENTATIVE TREATMENT IN PATIENTS WITH BARRETT'S METAPLASIA

AUTHOR(S)
Harries, K.; Jenkins, G. J. S.; Doak, S. H.; Griffiths, A. P.; Parry, J. M.; Baxter, J. N.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA63
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article presents a study stating that vitamin C inhibits nuclear factor activation in oesophageal cells exposed to deoxycholic acid. This is looked at as a potential cancer preventative treatment in patients with Barrett's metaplasia. Vitamin C appears to provide protection against cancer development, although the mechanism of action is not entirely clear. Nuclear factor is an antiapoptotic, pro-inflammatory transcription factor that has been known to play a major role in carcinogenesis. This study aims to identify whether vitamin C has any effect on deoxycholic acid induced nuclear factor activation.
ACCESSION #
13219058

 

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