TITLE

MORTALITY RISK FACTORS AND COMORBIDITY IN PATIENTS WITH BARRETT'S METAPLASIA

AUTHOR(S)
Enaganti, S. K.; Maayyedi, P.; Jankowski, J. A.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA62
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article studies the mortality risk factors and comorbidity in patients with Barrett's metaplasia. Barrett's metaplasia is a recognised precursor lesion for oesophageal adenocarcinoma. However it is recognised that most patients with Barrett's have other comorbidities. The study aimed to assess the cause of death of patients with Barrett's in an attempt to clarify whether these patients should be screened for other diseases. It shows that twice as many die of cardiovascular disease as those who die from oesophageal adenocarcinoma. This is clear justification for both cardiac protection as well as chemoprevention in this group of patients.
ACCESSION #
13219054

 

Related Articles

  • Barrett's Esophagus on Repeat Endoscopy: Should We Look More Than Once? Rodriguez, Sarah; Mattek, Nora; Lieberman, David; Fennerty, Brian; Eisen, Glenn // American Journal of Gastroenterology;Aug2008, Vol. 103 Issue 8, p1892 

    BACKGROUND: Barrett's esophagus (BE) is the precursor lesion for esophageal adenocarcinoma. The major risk factor for BE is chronic gastroesophageal reflux disease (GERD). Screening patients with longstanding GERD for BE with upper esophagogastroduodenoscopy (EGD) has become the standard...

  • Restoration of the Normal Squamous Lining in Barrett's Esophagus by Argon Beam Plasma Coagulation. Byrne, James P.; Armstrong, Gordon R.; Attwood, Stephen E. A. // American Journal of Gastroenterology;Oct1998, Vol. 93 Issue 10, p1810 

    Objective: Barrett's esophagus is associated with significantly increased risk of development of esophageal adenocarcinoma. Replacing columnar epithelium with the normal squamous lining in this condition offers the possibility of decreasing the risk of degeneration to invasive adenocarcinoma....

  • THE IMPORTANCE OF CYTOKERATINS 7 AND 20 IMMUNOHISTOCHEMISTRY IN THE DISTINCTION OF GASTRO-ESOPHAGEAL ADENOCARCINOMAS. Voinescu, Doina-Carina; Comanescu, Violeta; Popescu, Carmen; Cruce, M. // Annals of the Romanian Society for Cell Biology;2009, Vol. 14 Issue 2, p144 

    The gastro-esophageal junction is regularly exposed to concentrated gastric acid and to a variety of nitrosating species, noxious agents that may contribute to carcinogenesis in this region. Adenocarcinomas of the gastric cardia and distal oesophagus are among the most deadly of all...

  • The Incidence of Adenocarcinoma in Barrett's Esophagus: A Prospective Study of 170 Patients Followed 4.8 Years. Drewitz, D. J.; Sampliner, R. E.; Garewal, H. S. // American Journal of Gastroenterology;Feb1997, Vol. 92 Issue 2, p212 

    Objectives: Barrett's esophagus is a premalignant condition defined by the presence of intestinal metaplasia in the esophagus. Estimates of the incidence of adenocarcinoma developing in patients with Barrett's esophagus vary widely. We prospectively followed a cohort of patients to define the...

  • Role of retinoid X receptor mRNA expression in Barrett's esophagus. Brabender, Jan; Lord, Reginald V.; Metzger, Ralf; Park, JiMin; Salonga, Dennis; Danenberg, Kathleen D.; Hölscher, Arnulf H.; Danenberg, Peter V.; Schneider, Paul M. // Journal of Gastrointestinal Surgery;May2004, Vol. 8 Issue 4, p413 

    The Barrett''s multistage process is characterized histopathologically by progression from Barrett''s intestinal metaplasia to Barrett''s esophagus with dysplasia and ultimately adenocarcinoma. Understanding of the molecular alterations in this multistage process may contribute to improved...

  • Interaction of environmental factors in oesophageal carcinogenesis. Manjunath, S.; Jankowski, J.A.Z // Journal of the Royal College of Surgeons of Edinburgh;Aug2000, Vol. 45 Issue 4, p260 

    Indicates that the interaction between the various environmental factors with genetic susceptibility seems to result in predictable succession of events following an esophagitis-metaplasia-dyspepsia-carcinoma sequence. Incidence of adenocarcinoma of the esophagus; Squamous cell carcinoma of the...

  • Role of Proton Pump Inhibitor on Esophageal Carcinogenesis and Pancreatic Acinar Cell Metaplasia Development: An Experimental In Vivo Study. Dall’Olmo, Luigi; Fassan, Matteo; Dassie, Elisa; Scarpa, Marco; Realdon, Stefano; Cavallin, Francesco; Cagol, Matteo; Battaglia, Giorgio; Pizzi, Marco; Guzzardo, Vincenza; Franceschinis, Erica; Pasut, Gianfranco; Rugge, Massimo; Zaninotto, Giovanni; Realdon, Nicola; Castoro, Carlo // PLoS ONE;Nov2014, Vol. 9 Issue 11, p1 

    Chronic gastro-duodenal reflux in the esophagus is a major risk for intestinal metaplasia and Barrett’s adenocarcinoma. A role for chronic use of proton pump inhibitor (PPI) in the increased incidence of esophageal adenocarcinoma in Western countries has been previously suggested. The aim...

  • Testosterone deficiency and replacement: Myths and realities. Grober, Ethan D. // Canadian Urological Association Journal;jui/aou2014 supplement 5, Vol. 8, pS145 

    Testosterone deficiency, or hypogonadism, is common and may have deleterious effects on men, including decreased overall well-being, reduced sexual function and bone loss. Despite data demonstrating strong links between testosterone deficiency and significant comorbid conditions (including type...

  • Hyperuricemia, Gout, and Cardiovascular Disease. Keenan, Robert T.; Pillinger, Michael H. // Bulletin of the NYU Hospital for Joint Diseases;2009, Vol. 67 Issue 3, p285 

    Multiple epidemiologic studies confirm an association between hyperuricemia and cardiovascular disease (CVD), but it remains uncertain whether hyperuricemia is an independent or dependent risk factor for CVD. The question is particularly complex since patients with gout frequently have multiple...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics