TITLE

AN ANTI-APOPTOTIC ROLE FOR GASTRIN IN BARRETT'S OESOPHAGUS

AUTHOR(S)
Harris, J. C.; Clarke, P. A.; Awan, A. K.; Jankowsla, J.; Watson, S. A.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA61
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article presents a study of an anti-apoptotic role for gastrin in Barrett's oesophagus. Barrett's oesophagus (BO) is a premalignant disorder of the distal oesophagus, characterised by a metaplastic change from normal squamous to intestinal type epithelium. This study assessed gastrin and cholecystokinin-type 2 receptor (CCK-2R) levels in normal and BO biopsy samples and related these to activation of the anti-apoptotic factor, protein kinase B/Akt (PKB/Akt). Exogenous gastrin via the CCK-2R up-regulates PKB/Akt phosphorylation in oesophageal cell lines.
ACCESSION #
13219052

 

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