TITLE

DEFECTIVE TGF-β SIGNALLING IN THE BARRETT'S METAPLASIA-DYSPLASI-ADENOCARCINOMA SEQUENCE

AUTHOR(S)
Onwuegbusi, B. A.; Fitzgerald, R. C.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA60
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article presents a study on the defective transforming growth factor β (TGF-β) signaling in the Barrett's metaplasia-dysplasi-adenocarcinoma sequence. TGF-β is a multifunctional cytokine that potently regulates epithelial cell proliferation. The signal pathway for TGF-β is a known tumour suppressive pathway, mutated in many gastrointestinal carcinomas. Given that abnormal proliferation is observed in the Barrett's metaplasia-dysplasia-carcinoma sequence, it was hypothesised that disruptions in TGF-β signalling may contribute to oesophageal adenocarcinoma.
ACCESSION #
13219048

 

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