Onwuegbusi, B. A.; Fitzgerald, R. C.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA60
Academic Journal
The article presents a study on the defective transforming growth factor β (TGF-β) signaling in the Barrett's metaplasia-dysplasi-adenocarcinoma sequence. TGF-β is a multifunctional cytokine that potently regulates epithelial cell proliferation. The signal pathway for TGF-β is a known tumour suppressive pathway, mutated in many gastrointestinal carcinomas. Given that abnormal proliferation is observed in the Barrett's metaplasia-dysplasia-carcinoma sequence, it was hypothesised that disruptions in TGF-β signalling may contribute to oesophageal adenocarcinoma.


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