TITLE

ANDROGEN RECEPTORS MAY ACT IN A PARACRINE MANNER IN ASSOCIATION WITH FIBROBLAST GROWTH FACTOR RECEPTORS TO REGULATE OESOPHAGEAL ADENOCARCINOMA GROWTH

AUTHOR(S)
Awan, A. K.; Clarke, P. A.; Grabowska, A.; Iltikhar, S. Y.; Watson, S. A.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA60
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article presents a study stating that androgen receptors (AR) may act in a paracrine manner in association with fibroblast growth factor receptors to regulate oesophageal adenocarcinoma growth. The role of AR in tumorigenesis, including transcription of fibroblast growth factors (FGF), is established in prostate cancer but not oesophageal adenocarcinoma, where incidence is increased in males. This study examined AR and FGF receptor status and serum testosterone levels in human oesophageal adenocarcinoma patients. In vivo growth of an oesophageal odenocarcinoma was assessed in mice of both sex and related to AR and FGF receptors.
ACCESSION #
13219046

 

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