Kelty, C. J.; Gough, M. D.; van Wyk, Q.; Stephenson, T. J.; Ackroyd, R.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA59
Academic Journal
Barrett's oesophagus (BO) is the major risk factor for adenocarcinoma of the oesophagus, which is increasing in incidence more rapidly than any other cancer in the Western world. The risk of developing carcinoma in BO has been expressed in a number of different ways, for example from 30-125 times increased risk, 1 in 52 to 1 in 441 patient years of follow up, 0.5-1% per year, and 10-15% lifetime risk. However, much of this is based upon historical data, and the criteria for making the diagnosis have become more stringent since many of these studies were published, although recent guidelines, by the British Society of Gastroenterology, do not require intestinal metaplasia to be present for the diagnosis. It has been shown that the intestinal metaplasia is required for the diagnosis of BO, and that this phenotype carries malignant potential.


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