TITLE

COX-2 EXPRESSION, CELLULAR PROLIFERATION, AND APOPTOSIS IN EOSINOPHILIC OESOPHAGITIS AND GASTRO-OESOPHAGEAL REFLUX DISEASE

AUTHOR(S)
Lewis, C. J.; Pritchard, S.; Armstrong, G.; Attwood, S. E. A.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA59
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Eosinophilic oesophagitis (EO) is a condition not frequently diagnosed, with patients presenting with intermittent odynophagia, dysphagia, and bolus obstruction, without any significant endoscopic or manometric findings. Some researchers still consider that it is caused by reflux disease, but authors feel this condition is related to an allergic response. To test their hypothesis they examined the cellular characteristics of EO and compared them to normal mucosa and to that of reflux oesophagitis. The results indicate that EO is unlikely to be related to the mucosal injury associated with gastro-oesophageal reflux, and that an allergic response is more likely.
ACCESSION #
13219041

 

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