TITLE

VARIABLE CYCLOOXYGENASE (COX)-2 EXPRESSION IN BARRETT'S ASSOCIATED ADENOCARCINOMA: RELATIONSHIP TO TUMOUR DIFFERENTIATION

AUTHOR(S)
Abdalla, S.; Sanderson, I. R.; Novelli, M. R.; Lovat, L. B.; Fitzgerald, R. C.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA58
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Population based studies, animal models, and cell line experiments suggest a strong association between cyclooxygenase (COX)-2 and human cancer. Barrett's oesophageal epithelium (BE) expresses more COX-2 compared with normal squamous epithelium (NE). However, there are conflicting data regarding COX-2 expression in oesophageal adenocarcinoma (AC). Therefore, the study was designed to examine COX-2 expression in BE and associated AC and investigate whether this is affected by the degree of differentiation. Differentiated oesophageal AC biopsies and cell lines tend to express more COX-2 than non-differentiated tumours. However, COX-2 expression is heterogeneous within tumours making immunohistochemistry more suitable than western blotting in examining COX-2 expression levels.
ACCESSION #
13219039

 

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