Hindmarsh, A.; Cheong, E.; Sams, V.; Igali, L.; Doleman, J.; Belshaw, N.; Lund, L.; Rhodes, M.; Johnson, I. T.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA58
Academic Journal
Prospective analysis of the morphological changes occurring in the oesophagus of male Sprague-Dawley rats after oesophagojejunostomy was studied. Following surgery 70 rats were randomised into 7 groups of 10 animals. The groups were sacrificed at 4 weekly intervals up to 28 weeks. Terminal pH measurements were mode at the level of the oesophagojejunal anostamosis, and the oesophagi examined. Reflux of jejunal contents into the lower oesophagus of rats induces a series of morphological changes similar to those observed in human duodenogastro-oesophageal reflux disease. Tumour initiation and progression seems to occur in the absence of an acidic stimulus.


Related Articles

  • The incidence of gastroesophageal reflux after transthoracic esophagocardio-myotomy without fundoplication: a long term follow-up. Lindenmann, Joerg; Maier, Alfred; Eherer, Andreas; Matzi, Veronika; Tomaselli, Florian; Smolle, Josef; Smolle-Juettner, Freyja Maria // European Journal of Cardio-Thoracic Surgery;Mar2005, Vol. 27 Issue 3, p357 

    Abstract: Objective: Evaluation of the long term results of Heller''s myotomy performed over a lateral thoracotomy without additional fundoplication. Methods: Forty patients (17 males, 23 females; mean age 43.2 years; range: 14–63 years) were operated between 1985 and 2000. Preoperative...

  • Roux-en-Y Reconstruction for Failed Fundoplication. Makris, Konstantinos I.; Lee, Tommy; Mittal, Sumeet K. // Journal of Gastrointestinal Surgery;Dec2009, Vol. 13 Issue 12, p2226 

    Background Redo fundoplication has acceptable outcomes in patients with failed previous fundoplications. However, a subset of patients require Roux-en-Y (RNY) reconstruction for symptom relief. Aim The aim of this study was to demonstrate safety and efficacy of RNY reconstruction for failed...

  • Outcome of Surgical Fundoplication for Extraesophageal (Atypical) Manifestations of Gastroesophageal Reflux Disease in Adults: A Systematic Review. Iqbal, Mohd; Batch, Andrew J.; Spychal, Robert T.; Cooper, Brian T. // Journal of Laparoendoscopic & Advanced Surgical Techniques;Dec2008, Vol. 18 Issue 6, p789 

    Background: A significant proportion of patients with gastroesophageal reflux disease (GERD) present with atypical symptoms (extraesophageal reflux; EER). The effectiveness of surgical fundoplication in treating classical reflux symptoms is well documented, but the role of surgery in alleviating...

  • Laparoscopic Treatment of Simultaneously Occurring Morgagni and Paraesophageal Hernias. Szentkereszty, Zsolt; Csáky, Gergely; Boland, Mehrdad Ghassem; Weisz, Richard; Sasi-Szabó, László; Gamal, Eldin Mohamed; Sápy, Péter // Journal of Laparoendoscopic & Advanced Surgical Techniques;Dec2006, Vol. 16 Issue 6, p626 

    A paraesophageal hernia was diagnosed in a 67-year-old female patient suffering from epigastric pain and gastroesophageal reflux disease. The patient underwent laparoscopy. Beside the paraesophageal hernia, a Morgagni hernia was also observed, with a significant part of the omentum herniated in...

  • Histological and Anatomic Changes in Barrett's Esophagus After Antireflux Surgery. Low, Donald E.; Levine, Douglas S.; Dail, David H.; Kozarek, Richard A. // American Journal of Gastroenterology;Jan1999, Vol. 94 Issue 1, p80 

    Objective: The best treatment approach for patients with documented Barrett's esophagus remains controversial. There is currently no well designed prospective study examining the effect of successful antireflux surgery on Barrett's esophagus. Methods: Fourteen patients with histologically proven...

  • Surgical trial investigating nocturnal gastroesophageal reflux and sleep (STINGERS). Cohen, J. A.; Arain, A.; Harris, P. A.; Byrne, D. W.; Holzman, M. D.; Sharp, K. W.; Richards, W. O. // Surgical Endoscopy;Mar2003, Vol. 17 Issue 3, p394 

    Background: Nocturnal reflux is important in the pathogenesis of esophagitis. The relationship between reflux and sleep is poorly understood, although data support both paradigms of nocturnal reflux causing arousal and nocturnal arousal allowing reflux. Furthermore, the effect of fundoplication...

  • Laparoscopic Nissen Fundoplication Offers High Patient Satisfaction with Relief of Extraesophageal Symptoms of Gastroesophageal Reflux Disease. Rakita, Steven; Villadolid, Desiree; Thomas, Ashley; Bloomston, Mark; Albrink, Michael; Goldin, Steven; Rosemurgy, Alexander // American Surgeon;Mar2006, Vol. 72 Issue 3, p207 

    Nissen fundoplication is applied for patients with gastroesophageal reflux disease (GERD), usually because of symptoms of esophageal injury. When presenting symptoms are extraesophageal, there is less enthusiasm for operative control of reflux because of concerns of etiology and efficacy. This...

  • Thoracoscopic Belsey fundoplication with 5-year outcomes. Champion, J.K. // Surgical Endoscopy;Aug2003, Vol. 17 Issue 8, p1212 

    Background:To determine the indications for a minimally invasive thoracic technique in gastroesophageal reflux disease (GERD), we conducted a retrospective review of outcomes with our first 21 thoracoscopic Belsey fundoplications.Methods:A thoracoscopic Belsey fundoplication was completed in 21...

  • Postoperative Motor Function and Mucosal Blood Flow of Lower Esophagus: Comparison between Terminal Esophagoproximal Gastrectomy and Esophageal Transection for Esophageal Varices. Tamura, Shigeyuki; Shiozaki, Hitoshi; Kobayashi, Kenji; Yano, Tokiharu; Yano, Hiroshi; Tahara, Hideaki; Mori, Takesada // American Journal of Gastroenterology;Jul1993, Vol. 88 Issue 7, p1065 

    Reflux esophagitis and anastomotic ulcer are potential complications associated with surgery for esophagogastric lesions. This study compared 10 cases following terminal esophagoproximal gastrectomy (TEPG) for esophageal varices and 20 cases following esophageal transection (ET) for esophageal...


Read the Article


Sign out of this library

Other Topics