TITLE

CHARACTERISATION OF A SURGICAL MODEL OF OESOPHAGEAL ADENOCARCINOMA IN THE RAT

AUTHOR(S)
Hindmarsh, A.; Cheong, E.; Sams, V.; Igali, L.; Doleman, J.; Belshaw, N.; Lund, L.; Rhodes, M.; Johnson, I. T.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA58
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Prospective analysis of the morphological changes occurring in the oesophagus of male Sprague-Dawley rats after oesophagojejunostomy was studied. Following surgery 70 rats were randomised into 7 groups of 10 animals. The groups were sacrificed at 4 weekly intervals up to 28 weeks. Terminal pH measurements were mode at the level of the oesophagojejunal anostamosis, and the oesophagi examined. Reflux of jejunal contents into the lower oesophagus of rats induces a series of morphological changes similar to those observed in human duodenogastro-oesophageal reflux disease. Tumour initiation and progression seems to occur in the absence of an acidic stimulus.
ACCESSION #
13219038

 

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