TITLE

GASTRIN INDUCES CYCLOOXYGENASE (COX)-2 EXPRESSION IN BARRETT'S OESOPHAGUS

AUTHOR(S)
Abdalla, A.; Sirieix, P. S.; Sanderson, I. R.; Fitzgerald, R. C.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA58
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The cyclooxygenase (COX)-2 enzyme is induced in inflammation and cancer. Furthermore, it is expressed in Barren's epithelium (BE) and associated adenocarcinoma (AC). However, there ore no previous longitudinal studies that examined COX-2 expression in the progression of BE to cancer. Furthermore, the possible role of gastrin in inducing COX-2 has not been analysed, although most BE patients use proton pump inhibitors that may cause moderate hypergastrinemia. It is also possible that there is autocrine production of gastrin by epithelial cells. COX-2 expression occurs early in BE and increases over time. Proton pump inhibitor induced and outocrine production of gastrin by epithelial cells in vivo may hove a role in inducing COX-2 in BE and AC.
ACCESSION #
13219037

 

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