Fletcher, J.; Wirz, A.; McColl, K. E. L.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA57
Academic Journal
After a meal there exists a pocket of unbuffered highly acidic gastric juice at the gastro-oesophageal (GO) junction. Authors observed that this post prandial acid pocket extended into the distal oesophagus. After the high fat meal there is proximal migration of the acid pocket resulting in a more proximal pH step up point. This is particularly seen in the upright position and was not apparent after the low fat meal. The ability of fat to open the distal part of the GO sphincter is likely to contribute to acid damage of the most distal oesophageal squamous mucosa.


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