TITLE

THE OESOPHAGEAL LUMEN HAS THE CHEMICAL CONDITIONS FOR GENERATING CARCINOGENIC N- NITROSO COMPOUNDS

AUTHOR(S)
Suzuki, H.; McElroy, K.; Scobie, G.; Fyfe, V.; McColl, K. E. L.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA56
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Bacteria in the oral cavity reduce 25% of the nitrate, absorbed from the diet and secreted into the mouth by the salivary glands to nitrite. Nitrite can be converted to carcinogenic N-nitroso compounds (NOC) by bacteria at neutral pH and non-bacterially at acidic pH catalysed by thiocyanate which is also secreted in saliva. The concentrations of the chemicals relevant to NOC generation have been studied previously in the mouth and the stomach but not in the nasal cavity, pharynx and different regions of the oesophagus. The oesophageal lumen contains high concentrations of nitrite and thiocyanate and thus provides the conditions for generation of N-nitroso compounds by bacteria at neutral pH or by acidification during reflux episodes. These compounds are likely to contribute to the development of both oesophageal squamous and adenocarcinoma.
ACCESSION #
13219030

 

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