TITLE

RISE IN OESOPHAGEAL ADENOCARCINOMA IS ACCOMPANIED BY SIMILAR RISE INORAL CANCER: EVIDENCE FOR ENVIRONMENTAL CARCINOGEN

AUTHOR(S)
McColl, K. E. L.; Winter, J.; Manning, J.; Paterson, S.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA56
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Oesophageal and gastric cardia adenocarcinoma have increased in incidence two to threefold in the Western world over the past 20 years. Scotland has the highest recorded incidence of such cancers. The high luminal concentrations of nitrite present in the oesophagus may contribute to oesophageol adenocarcinoma as it can be converted to carcinogenic N-nitroso compounds by bacteria or acid. In Scotland, the rise in oesophageat adenocarcinoma has been accompanied by a similar rise in oral carcinoma and also significant increase in oesophageal squamous carcinoma. The rise in these cancers is occurring 20 years alter the marked rise in nitrogenous fertiliser usage which is the source of dietary nitrate.
ACCESSION #
13219029

 

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