McColl, K. E. L.; Winter, J.; Manning, J.; Paterson, S.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA56
Academic Journal
Oesophageal and gastric cardia adenocarcinoma have increased in incidence two to threefold in the Western world over the past 20 years. Scotland has the highest recorded incidence of such cancers. The high luminal concentrations of nitrite present in the oesophagus may contribute to oesophageol adenocarcinoma as it can be converted to carcinogenic N-nitroso compounds by bacteria or acid. In Scotland, the rise in oesophageat adenocarcinoma has been accompanied by a similar rise in oral carcinoma and also significant increase in oesophageal squamous carcinoma. The rise in these cancers is occurring 20 years alter the marked rise in nitrogenous fertiliser usage which is the source of dietary nitrate.


Related Articles

  • THE OESOPHAGEAL LUMEN HAS THE CHEMICAL CONDITIONS FOR GENERATING CARCINOGENIC N- NITROSO COMPOUNDS. Suzuki, H.; McElroy, K.; Scobie, G.; Fyfe, V.; McColl, K. E. L. // Gut;Apr2004 Supplement 3, Vol. 53, pA56 

    Bacteria in the oral cavity reduce 25% of the nitrate, absorbed from the diet and secreted into the mouth by the salivary glands to nitrite. Nitrite can be converted to carcinogenic N-nitroso compounds (NOC) by bacteria at neutral pH and non-bacterially at acidic pH catalysed by thiocyanate...

  • Association between body mass and adenocarcinoma of the esophagus and gastric cardia. Lagergren, Jesper; Bergstrom, Reinhold // Annals of Internal Medicine;06/01/99, Vol. 130 Issue 11, p883 

    Examines the relationship between body mass index (BMI) and development of adenocarcinoma of the esophagus and gastric cardia. Dose-dependent relation between BMI and esophageal adenocarcinoma; Odds ratio in patients with either esophageal or gastric cardia adenocarcinoma; No significant...

  • Rising Incidence of Adenocarcinoma of the Esophagus and Gastric Cardia. Blot, William J.; Devesa, Susan S.; Kneller, Robert W.; Fraumeni, Joseph F. // JAMA: Journal of the American Medical Association;3/13/91, Vol. 265 Issue 10, p1287 

    Examines the rising incidence of patients with adenocarcinoma of the esophagus and gastric cardia in the U.S. from 1976 to 1987. Trends in squamous cell carcinomas of the esophagus; Histologic categories of esophageal cancers; Patterns of esophageal and gastric cardia adenocarcinomas.

  • Carcinoma of the cardia: classification as esophageal or gastric cancer? Von Rahden, Burkhard H. A.; Feith, Marcus; Stein, Hubert J. // International Journal of Colorectal Disease;Mar2005, Vol. 20 Issue 2, p89 

    Introduction: The cardia is the anatomical borderland between the esophagus and stomach. Carcinomas of the cardia are regarded to share features of both, esophageal and gastric cancers. Controversy exists concerning their appropriate classification and whether these tumors comprise-in respect to...

  • Maternal characteristics associated with the dietary intake of nitrates, nitrites, and nitrosamines in women of child-bearing age: a cross-sectional study. Griesenbeck, John S.; Brender, Jean D.; Sharkey, Joseph R.; Steck, Michelle D.; Huber Jr, John C.; Rene, Antonio A.; McDonald, Thomas J.; Romitti, Paul A.; Canfield, Mark A.; Langlois, Peter H.; Suarez, Lucina // Environmental Health: A Global Access Science Source;2010, Vol. 9, p10 

    Background: Multiple N-nitroso compounds have been observed in animal studies to be both mutagenic and teratogenic. Human exposure to N-nitroso compounds and their precursors, nitrates and nitrites, can occur through exogenous sources, such as diet, drinking water, occupation, or environmental...

  • Continuing Rapid Increase in Esophageal Adenocarcinoma in England and Wales. Lepage, Côme; Rachet, Bernard; Jooste, Valérie; Faivre, Jean; Coleman, Michel P. // American Journal of Gastroenterology;Nov2008, Vol. 103 Issue 11, p2694 

    BACKGROUND AND AIMS: Substantial changes have occurred in the epidemiology of esophageal adenocarcinoma. We examined trends in incidence in a large national population. METHODS: All esophageal adenocarcinomas registered in England and Wales over a 31-year period (1971–2001) were...

  • Prevalence of Barrett's esophagus and expression of mucin antigens detected by a panel of monoclonal antibodies in Barrett's esophagus and esophageal adenocarcinoma in Japan. Azuma, Naoki; Endo, Takao; Arimura, Yoshiaki; Motoya, Satoshi; Itoh, Fumio; Hinoda, Yuji; Irimura, Tatsuro; Hosokawa, Masao; Imai, Kohzoh // Journal of Gastroenterology;2000, Vol. 35 Issue 8, p583 

    Abstract: Barrett's esophagus (BE) is an acquired disorder associated with a high incidence of adenocarcinoma of the lower esophagus. Moreover, it has been reported that short-segment BE may be associated with adenocarcinoma of the esophagogastric junction. The objective of this study was to...

  • Leukotriene A[sub 4] Hydrolase in Rat and Human Esophageal Adenocarcinomas and Inhibitory Effects of Bestatin. Xiaoxin Chen; Ning Li; Shah, Keerti V.; Anastos, Kathryn; Klein, Robert S.; Minkoff, Howard; Duerr, Ann; Massad, L. Stewart; Celentano, David D.; Hall, Charles; Fazzari, Melissa; Cu-Uvin, Susan; Bacon, Melanie; Schuman, Paula; Levine, Alexandra M.; Durante, Amanda J.; Gange, Stephen; Melnick, Sandra; Burk, Robert D. // JNCI: Journal of the National Cancer Institute;7/16/2003, Vol. 95 Issue 14, p1053 

    Background.' Esophageal adenocarcinoma (EAC) is increasing at the most rapid rate of any cancer in the United States. An esophagogastroduodenal anastomosis (EGDA) surgical model in rats mimics human gastroesophageal reflux and results in EAC. Leukotriene A[sub 4] hydrolase (LTA[sub 4]H), a...

  • SWOG S0356: Combination therapy failed to meet endpoint in esophageal adenocarcinoma.  // Hem/Onc Today;11/25/2011, Vol. 12 Issue 22, p9 

    The article presents a study that examined the pathologic complete response of the SWOG S0356 combination treatment for patients with esophageal adenocarcinoma.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics