Gatenby, P.; Caygill, C.; Ramus, J.; Watson, A.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA55
Academic Journal
Columnar lined oesophagus (CLO) has been recognised as the main predictive indicator of oesophageal adenocarcinoma (AC). However, controversy exists as to the level of risk of malignant transformation from different histological features and this has not been studied previously in a large series in Great Britain. Data from this cohort demonstrate an escalating risk of AC with histology, particularly in the presence of dysplasia. The AC incidence in low grade dysplasia is 5.3% and in high grade dysplasia 50%. However, the absence of histologically documented intestinal metaplasia and the presence of short segment CLO are both associated with adenocarcinoma development.


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