Pell, R. J.; Barley, N. F.; Khair, U.; Walters, J. R. F.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA40
Academic Journal
This article focuses on a study related to polymorphisms in the ileal bile acid binding protein gene in subjects with diarrhoea. Bile acid malabsorption is a relatively common cause of diarrhoea and is frequently secondary to resection of the terminal ileum. Idiopathic, primary, bile acid malabsorption can present as post infective, or diarrhoea predominant irritable bowel syndrome. Researchers include that genetic variation is common in the ileal bile acid binding protein gene and is a potential cause of functional abnormalities in bile acid absorption.


Related Articles

  • dPORE-miRNA: Polymorphic Regulation of MicroRNA Genes. Schmeier, Sebastian; Schaefer, Ulf; MacPherson, Cameron R.; Bajic, Vladimir B. // PLoS ONE;2011, Vol. 6 Issue 2, p1 

    Background: MicroRNAs (miRNAs) are short non-coding RNA molecules that act as post-transcriptional regulators and affect the regulation of protein-coding genes. Mostly transcribed by PolII, miRNA genes are regulated at the transcriptional level similarly to protein-coding genes. In this study we...

  • Left Ventricular Non-Compaction Associated with a Genetic Variant of the CYP2C9 Gene. Bohrer, Thomas; Klein, Hanns-Georg; Elert, Olaf // Heart, Lung & Circulation;Aug2006, Vol. 15 Issue 4, p269 

    Polymorphisms in the CYP2C9 gene can have a significant impact on drug therapy by affecting the pharmacokinetics of frequently prescribed drugs, such as phenprocoumon and warfarin. It is essential therefore that genetic CYP2C9 variants are excluded in patients with a suspected intolerance of...

  • Exploiting large scale computing to construct high resolution linkage disequilibrium maps of the human genome. Winston Lau; Tai-Yue Kuo // Bioinformatics;Feb2007, Vol. 23 Issue 4, p517 

    Summary: Linkage disequilibrium (LD) maps increase power and precision in association mapping, define optimal marker spacing and identify recombination hot-spots and regions influenced by natural selection. Phase II of HapMap provides ∼2.8-fold more single nucleotide polymorphisms (SNPs)...

  • Genetic mapping of the pear scab resistance gene Vnk of Japanese pear cultivar Kinchaku. Terakami, S.; Shoda, M.; Adachi, Y.; Gonai, T.; Kasumi, M.; Sawamura, Y.; Iketani, H.; Kotobuki, K.; Patocchi, A.; Gessler, C.; Hayashi, T.; Yamamoto, T. // Theoretical & Applied Genetics;Aug2006, Vol. 113 Issue 4, p743 

    Pear scab (caused by Venturia nashicola) is one of the most harmful diseases of pears, especially Japanese and Chinese pear species. The molecular identification and early selection of resistant plants could greatly improve pear breeding. We have identified the position of the scab resistance...

  • Polymorphism of Trp64Arg in β3-adrenergic receptor gene and serum LDL-cholesterol concentrations in healthy Japanese. Kotani, Kazuhiko; Sakane, Naoki; Kurozawa, Youichi; Kaetsu, Akihiko; Okamoto, Mikizo; Osaki, Yoneatsu; Kishimoto, Takuji // Annals of Clinical Biochemistry;May2008, Vol. 45 Issue 3, p313 

    Background: Polymorphism of Trp64Arg in the β3-adrenergic receptor (β3-AR) gene may play a critical role in lipid and lipoprotein metabolism by mediating lipolysis and thermogenesis. Since the frequency of Arg alleles of the β3-AR gene is generally low among many populations, studies on...

  • A Taq I PCR-RFLP Detecting a Novel SNP in Exon 2 of the Bovine POU1F1 Gene. Chuanying Pan; Xianyong Lan; Yikun Guo; Jianhong Shu; Chuzhao Lei; Xinzhuang Wang // Biochemical Genetics;Aug2008, Vol. 46 Issue 7/8, p424 

    Abstract  PCR-SSCP and DNA sequencing methods were applied to reveal three novel single nucleotide polymorphisms (SNPs) in exon 2 of the POU1F1 gene in 963 Chinese cattle belonging to eight breeds. Among them, a silent SNP (NM_174579:c.545G > A) detected by TaqI endonuclease is...

  • The Tc1/mariner transposable element family shapes genetic variation and gene expression in the protist Trichomonas vaginalis. Bradic, Martina; Warring, Sally D.; Low, Vivien; Carlton, Jane M. // Mobile DNA;2014, Vol. 5 Issue 1, p1 

    Background: Trichomonas vaginalis is the most prevalent non-viral sexually transmitted parasite. Although the protist is presumed to reproduce asexually, 60% of its haploid genome contains transposable elements (TEs), known contributors to genome variability. The availability of a draft genome...

  • Sample-size properties of a case-control association analysis of multistage SNP studies for identifying disease susceptibility genes. Kitamura, Nobutaka; Akazawa, Kouhei; Toyabe, Shin-ichi; Miyashita, Akinori; Kuwano, Ryozo; Nakamura, Junichiro // Journal of Human Genetics;May2008, Vol. 53 Issue 5, p390 

    A two-stage association study is the most commonly used method to efficiently identify disease susceptibility genes. However, some recent single nucleotide polymorphism (SNP) studies recently utilized three-stage designs. The purpose of this study was to investigate the practical properties of...

  • Single nucleotide polymorphism, haplotype diversity and recombination in the Isa gene of barley. Bundock, P. C.; Henry, R. J. // Theoretical & Applied Genetics;Aug2004, Vol. 109 Issue 3, p543 

    The Isa gene from barley—an intronless gene expressed in maternal tissues of the seed—has a likely role in defence against pathogens. The protein product—bi-functional α-amylase/subtilisin inhibitor—inhibits the seed’s own amylase in addition to the...


Read the Article


Sign out of this library

Other Topics