TITLE

COMPARISON OF HYDROGEN SULPHIDE DETOXIFICATION ENZYME MRNA EXPRESSION IN NORMAL AND ULCERATIVE COLITIS RECTAL MUCOSAE

AUTHOR(S)
Kong, S. C.; Furrie, E.; Madden, J.; Kennedy, A.; Magee, E.; Mocfarlane, G. T.; Cummings, J. H.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA37
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This article focuses on a study that compares hydrogen sulphide (H2S) detoxification enzyme mRNA expression in normal and ulcerative colitis rectal mucosae. H2S) produced in the colon is toxic to the colonic mucosa and may be involved in the pathogenesis of ulcerative colitis (UC). The ability of UC mucosa to detoxify H2S may be impaired. The low level of SO detected and the lack of difference between the two patient groups suggests that this enzyme does not play an important role in H2S detoxification in the colon.
ACCESSION #
13218958

 

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