TITLE

BILE FLOW AND COMPOSITION ARE MODULATED BY INTRAVENOUS GLYCINE IN AN IN VIVO WARM ISCHAEMIA REPERFUSION INJURY MODEL

AUTHOR(S)
Hafez, T.; Sheth, H.; Glantzounis, G.; Yang, W.; Parks, H. G.; Seifalian, A.; Fuller, B.; Davidson, B. R.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA36
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This article focuses on a study that suggests bile flow and composition are modulated by intravenous glycine in an in vivo warm ischaemia reperfusion injury model. Liver ischemia reperfusion injury is a major complication of liver resection and transplantation. The cytokine release by activated Kuppfer cells (KCs) plays a central role and glycine inhibits KC activity. 5 mg/k9 IV glycine 1 hour prior to 60 mm ischemia normalised bile flow and was associated with a significantly altered bile composition.
ACCESSION #
13218955

 

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