TITLE

SEP53 AND AG-2 MAY ACT AS PROTO-ONCOGENES IN BARRETT'S METAPLASIA

AUTHOR(S)
Dalziel, H. H.; Pohler, E.; Quayle, L.; Cotton, J. P.; Hupp, T. R.; Dillon, J. F.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA35
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This article focuses on a study that suggests that SEP53 and AG-2 may act as proto-oncogenes in barrett's metaplasia. The adverse environment the oesophagus is exposed to induces heat shock proteins. A novel stress response was found operating in the oesophogeal epithelium. Gene constructs for SEP53 and AG-2 were transfected into H1299 cells in a colony proliferation assay. Whether the expression of both proteins in the same cell would be synergistic for proliferation and dysplastic change requires further investigation.
ACCESSION #
13218950

 

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