TITLE

THIOPURINE METHYL TRANSFERASE ACTIVITY PREDICTS BOTH TOXICITY AND CLINICAL RESPONSE TO AZATHIOPRINE IN INFLAMMATORY BOWEL DISEASE: THE LONDON IBD FORUM PROSPECTIVE STUDY

AUTHOR(S)
Ansari, A.; Arenas, M.; Lindsay, J.; Morris, D.; Greenfield, S.; Khanbai, T.; Fong, F.; Aslam, Z.; Fairbanks, L.; Morinaki, A.; Duley, J.; Sanderson, J.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA32
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Thiopurine methyl transferase (TPMT) deficiency increases the catabolism of azathioprine (AZA) to cytotoxic thioguanine nucleotides, leading to increased toxicity. Theoretically, higher TPMT activity should also predict a poor response to treatment but this has only been suggested in retrospective studies. This prospective confirms the importance of TPMT deficiency in predicting toxicity on AZA, particularly nausea and myelotoxicity.
ACCESSION #
13218938

 

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