Lai, W.; Sun, P.; Zhang, J.; McKeating, J.; Adams, D.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA30
Academic Journal
LSIGN, a type 2 C type lectin expressed on HSEC can bind with high affinity to HCV E2 glycoprotein. Primary HSEC were isolated from donor liver tissue using standard methods. DCSIGN and LSIGN expression was detected by RI-PCR, flow cytometry, and immunohistochernistry. The different distribution of LSIGN and LSIGN in the liver and the ability of both lectins to bind HCV E2 suggest a complementary role in HCV trapping and uptake within the liver.The ability of IL-4 to increase LSIGN expression suggests a novel mechanism by which this cytokine may regulate HCV cell attachment and infectivity.


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