TITLE

DERANGED SMOOTH MUSCLE α-ACTIN: A BIO-MARKER OF INTESTINAL PSEUDO-OBSTRUCTION. A CONTROLLED MULTINATIONAL CASE SERIES AND ONTOLOGICAL STUDY

AUTHOR(S)
Knowles, C. H.; Silk, D. B. A.; Darzi, A.; Feakins, R.; Raimundo, A. H.; Veress, B.; Crompton, T.; Lindberg, G.; Martin, J. E.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA29
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Chronic idiopathic intestinal pseudo-obstruction (CIIP) is a severe motility disorder associated with significant morbidity. Several histopathological phenotypes have been described, but only a single adult with jejunal smooth muscle α-actin deficiency. This article present a prospective multinational case series of 131 fully clinically and physiologically characterised CIIP patients from 3 European centres investigating smooth muscle α-actin deficiency as a biomarker of this disease.
ACCESSION #
13218929

 

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