Knowles, C. H.; Silk, D. B. A.; Darzi, A.; Feakins, R.; Raimundo, A. H.; Veress, B.; Crompton, T.; Lindberg, G.; Martin, J. E.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA29
Academic Journal
Chronic idiopathic intestinal pseudo-obstruction (CIIP) is a severe motility disorder associated with significant morbidity. Several histopathological phenotypes have been described, but only a single adult with jejunal smooth muscle α-actin deficiency. This article present a prospective multinational case series of 131 fully clinically and physiologically characterised CIIP patients from 3 European centres investigating smooth muscle α-actin deficiency as a biomarker of this disease.


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