TITLE

PATTERNS OF β-CATENIN STAINING AND DOWN- STREAM TARGETS OF β-CATENIN/TCY/LEF TRANSCRIPTION REVEAL MODES OF GROWTH OF COLORECTAL ADENOMAS: EVIDENCE AGAINST "TOP DOWN" AS A MAJOR COMPONENT

AUTHOR(S)
Preston, S. L.; Oukrif, D.; Kyriakides, A.; Elia, G.; Talbot, I. C.; Tomlinson, I. P.; Direkze, N. C.; Lipton, L.; Novelli, M.; Wright, N. A.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA29
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The top down concept of the clonal expansion of colorectal odenomas has been quick to seize the imagination of workers in the field. In this article a large cohort of different adenoma types is analyzed to establish its prevalence. It was found that top down spread is rare and associated with a villous format. Adenomatous crypts are mainly formed by fission or by growth between pre-existing crypts to form new crypts. The loss of nuclear 13-catenin indicates positional regulation and reversal of proliferation is a feature of larger lesions.
ACCESSION #
13218928

 

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