TITLE

EXPRESSION OF CANNABINOID CR-1 RECEPTORS BY VAGAL AFFERENT NEURONES AND INHIBITION BY CHOLECYSTOKININ (CCK)

AUTHOR(S)
Burdygo, G.; Lal, S.; Varro, A.; Dimaline, R.; Thompson, D. G.; Dodcray, G. J.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA28
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Both inhibitory and stimulatory factors from the gastrointestinal tract regulate food intake. In the case of the satiety peptide CCK these effects are mediated via vagal afferent nerve fibres. Since endogenous cannabinoid (CB)1 receptors are associated with stimulation of appetite, it is enquired whether vagal afferent neurones that express CCK- 1 receptors also express CB1 receptors. It was found that cannabinoid CB1 receptors are expressed by rat vagal afferent neurones. CB1 expression is increased in fasting and is downregulated by CCK and CCK modulation of CB1 receptor expression may contribute to control of appetite.
ACCESSION #
13218925

 

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