TITLE

BACTERIAL ENTEROTOXINS STIMULATE RELEASE OF THE NEUROTRANSMITTER [³H] NORADRENALINE FROM NEURONALLY DIFFERENTIATED PC12 CELLS

AUTHOR(S)
Casbum-Jones, A. C.; Barnett, S. C.; Forthing, M. J. G.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA28
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The bacterial enterotoxins cholera toxin, Escherichia coli heat labile (LT) and heat stable toxins are thought in part to mediate intestinal secretion through an enteric reflex arc. These toxins may activate a secretory response by interacting directly with enteric nerves. Previously it was shown that a and LT induce neurite outgrowth in PC12 cells and enhance the neuronal differentiation effects of nerve growth factor. A direct functional effect of these enterotoxins was investigated by measuring neurotransmitter release.
ACCESSION #
13218924

 

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