TITLE

SENSITISATION V HYPERVIGILANCE: IDENTIFYING THE NEUROPHYSIOLOGICAL MECHANISMS OF VISCERAL HYPERSENSITIVITY IN NON-CARDIAC CHEST PAIN

AUTHOR(S)
Hobson, A. R.; Willert, R. P.; Mathews, P. J. M.; Bancewicz, J.; Thompson, D. G.; Aziz, Q.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA27
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
One of the major problems encountered by researchers studying the aetiology of non-cardiac chest pain (NCCP) is the heterogeneity of the group. While visceral hypersensitivity (VH) is thought to be important in the generation of symptoms in NCCP, conventional physiological assessments do not allow one to objectively investigate or differentiate between the potential neurophysiological mechanisms that may cause it. This study aims to explore the neurophysiological basis for VH in NCCP. The potentiation of oesophageal evoked potentials components in group 2 patients indicates enhanced oesophogeal afferent transmission, similar to that seen following the induction of experimental oesophageal sensitisation.
ACCESSION #
13218921

 

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