Hobson, A. R.; Willert, R. P.; Mathews, P. J. M.; Bancewicz, J.; Thompson, D. G.; Aziz, Q.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA27
Academic Journal
One of the major problems encountered by researchers studying the aetiology of non-cardiac chest pain (NCCP) is the heterogeneity of the group. While visceral hypersensitivity (VH) is thought to be important in the generation of symptoms in NCCP, conventional physiological assessments do not allow one to objectively investigate or differentiate between the potential neurophysiological mechanisms that may cause it. This study aims to explore the neurophysiological basis for VH in NCCP. The potentiation of oesophageal evoked potentials components in group 2 patients indicates enhanced oesophogeal afferent transmission, similar to that seen following the induction of experimental oesophageal sensitisation.


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