Japp, A.; Chui, M.; Waring, S.; Nicol, F.; Frad, M.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA27
Academic Journal
Altered autonomic function has been reported both in irritable bowel syndrome (IBS) and in anxiety and depression disorders and may contribute to abnormalities of gastrointestinal motility and visceral hypersensitivity. It is hypothesised that alterations in autonomic function may reflect increased central nervous system arousal associated with anxiety and depression as assessed using Hospital Anxiety and Depression (HAD) rating scale. It was found that patients with IBS demonstrate decreased parasympathetic and increased sympathetic responses to cardiovascular stimulation, which did not correlate with HAD ratings.


Related Articles

  • Effects of NB001 and gabapentin on irritable bowel syndrome-induced behavioral anxiety and spontaneous pain. Ming-Ming Zhang; Shui-Bing Liu; Tao Chen; Kohei Koga; Ting Zhang; Yun-Qing Li; Min Zhuo // Molecular Brain;2014, Vol. 7 Issue 1, p2 

    Irritable bowel syndrome (IBS) is characterized by recurrent abdominal discomfort, spontaneous pain, colorectal hypersensitivity and bowel dysfunction. Patients with IBS also suffer from emotional anxiety and depression. However, few animal studies have investigated IBS-induced spontaneous pain...

  • Overlap in Patients With Dyspepsia/Functional Dyspepsia. Yasuhiro Fujiwara; Tetsuo Arakawa // Journal of Neurogastroenterology & Motility;Oct2014, Vol. 20 Issue 4, p447 

    Patients with dyspepsia/functional dyspepsia (FD) show frequent overlapping of other gastrointestinal (GI) diseases, such as irritable bowel syndrome, and non-GI diseases, in addition to internal subgroup overlapping. These overlap patients have more frequent or more severe symptoms, poorer...

  • Recent insights into digestive motility in functional dyspepsia. Mizuta, Yohei; Shikuwa, Saburo; Isomoto, Hajime; Mishima, Ryosuke; Akazawa, Yuko; Masuda, Jun-ichi; Omagari, Katsuhisa; Takeshima, Fuminao; Kohno, Shigeru // Journal of Gastroenterology;Nov2006, Vol. 41 Issue 11, p1025 

    Functional gastrointestinal disorders, such as functional dyspepsia (FD) and irritable bowel syndrome, are common pathologies of the gut. FD is a clinical syndrome defined as chronic or recurrent pain or discomfort of unknown origin in the upper abdomen. The pathophysiological mechanisms...

  • Enhanced preattentive central nervous system reactivity in irritable bowel syndrome. Berman, Steven M.; Naliboff, Bruce D.; Chang, Lin; FitzGerald, Leah; Antolin, Tim; Camplone, Art; Mayer, Emeran A. // American Journal of Gastroenterology;Nov2002, Vol. 97 Issue 11, p2791 

    OBJECTIVE:Irritable bowel syndrome (IBS) is a common functional disorder characterized by enhanced perceptual sensitivity and hypervigilance toward afferent signals from the viscera. We hypothesize that the increased responsiveness of IBS patients is a generalized phenomenon applying to stimuli...

  • Current status of functional gastrointestinal evaluation in clinical practice. Ang, Daphne; Kwong Ming Fock; Ngai Moh Law; Tiing Leong Ang // Singapore Medical Journal;2015, Vol. 56 Issue 2, p69 

    Neurogastroenterology and motility disorders of the gastrointestinal (GI) tract encompass a broad spectrum of diseases involving the GI tract and central nervous system. They have varied pathophysiology, clinical presentation and management, and make up a substantial proportion of outpatient...

  • Elevated expression of c-fos in central nervous system correlates with visceral hypersensitivity in irritable bowel syndrome (IBS): a new target for IBS treatment. Ru Zhang; Ning Zou; Ji Li; Hong Lv; Jing Wei; Xiu-Cai Fang; Jia-Ming Qian // International Journal of Colorectal Disease;Aug2011, Vol. 26 Issue 8, p1035 

    Background and aims: Although visceral hypersensitivity is a major pathophysiological feature of irritable bowel syndrome (IBS), its molecular mechanisms are still poorly understood. c-fos is a well-established marker of cell activation. Accumulating evidence demonstrates that norepinephrine...

  • Increased rectal mucosal expression of interleukin 1β in recently acquired post-infectious irritable bowel syndrome. Gwee, K.-A.; Collins, S.M.; Read, N.W.; Rajnakova, A.; Deng, Y.; Graham, J.C.; McKendrick, M.W.; Moochhala, S.M. // Gut;Apr2003, Vol. 52 Issue 4, p523 

    Background and aims: Chronic bowel disturbances resembling irritable bowel syndrome (lBS) develop in approximately 25% of patients after an episode of infectious diarrhoea. Although we have previously shown that psychosocial factors operating at the time of, or prior to, the acute illness appear...

  • Exaggerated motility of the descending colon with repetitive distention of the sigmoid colon in patients with irritable bowel syndrome. Fukudo, Shin; Kanazawa, Motoyori; Kano, Michiko; Sagami, Yasuhiro; Endo, Yuka; Utsumi, Atsushi; Nomura, Taisuke; Hongo, Michio // Journal of Gastroenterology;2002 Supplement 14, Vol. 37 Issue 11, p145 

    Background. Visceral hypersensitivity is one of the mechanisms of irritable bowel syndrome (IBS), but it does not explain the entire symptomatology, i.e., altered bowel habit with abdominal pain relieved by defecation. We tested our hypothesis that an abnormal link between luminal stimulation...

  • Fluoxetine interaction.  // Reactions Weekly;5/21/2005, Issue 1052, p10 

    Examines the case of a 34-year-old woman receiving tegaserod for irritable bowel syndrome who developed a panic disorder during treatment with fluoxetine for depression. Improvement of her condition after tegaserod was discontinued; Recurrence of symptoms of irritable bowel syndrome.


Read the Article


Sign out of this library

Other Topics