Lee, G.; Lund, E. K.; Rhodes, M.; Johnson, I. T.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA26
Academic Journal
Oesophageal adenocarcinoma initiation and progression is associated with elevated levels of cyclo-oygenase 2 (COX-2) expression. The use of synthetic COX-2 inhibitors as chemo-preventative therapy is limited by side effects. There is epidemiological and experimental evidence to suggest that certain n-3 fatty acids have a protective effect, which may be mediated through inhibition of COX-2 expression. This article investigate the suppressive effect of EPA on COX-2 gene expression in a human oesophageal adenocarcinoma cell line.


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