TITLE

FOVEOLIN IS ABUNDANTLY AND SPECIFICALLY EXPRESSED IN SUPERFICIAL GASTRIC EPITHELIUM, DOWN REGULATED IN GASTRIC CARCINOMA, AND SHOWS HIGH EVOLUTIONARY CONSERVATION

AUTHOR(S)
Oien, K. A.; McGregor, F.; Butler, S.; Ferrier, R. K.; Downie, I.; Bryce, S.; Burns, S.; Keith, W. N.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA24
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This article presents a study which states that foveolin is abundantly and specifically expressed in superficial gastric epithelium, down regulated in gastric carcinoma and shows high evolutionary conservation. Through previous large scale gene expression profiling, a transcript was identified, which was abundant in normal stomach and down regulated in gastric cancer. Genes expressed at similar levels included gastrin, MUC5 and p52, which are important in gastric function. Foveolin's abundance in and specificity to native or metaplastic gastric epithelium, down regulation in gastric carcinomas and evolutionary conservation suggest that this gene is physiologically important in the stomach.
ACCESSION #
13218906

 

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