TITLE

THE IL-8-251 PROMOTER POLYMORPHISM IS ASSOCIATED WITH HIGH IL-8 PRODUCTION, SEVERE INFLAMMATION, AND INCREASED RISK OF PRE- MAILGNANT CHANGES IN H PYLORI POSITIVE SUBJECTS

AUTHOR(S)
Smith, M. G.; Hold, G. H.; Mowat, N. A. G.; McColl, K. E.; El-Omar, E. M.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA23
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This article presents a study which states that the interleukin (IL)-8-251 promoter polymorphism is associated with high IL-8 production, severe inflammation and increased risk of pre-malignant changes in H pylori positive subjects. IL-8 is a key cytokine in the pathogenesis of H pylori related disease. It is a powerful chemotactic factor that induces many of the early inflammatory responses to H pylori infection. A recently described single nucleotide promoter polymorphism at position -251 (A/T) has been associated with viral bronchiolitis.
ACCESSION #
13218903

 

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