TITLE

AGEING AND H PYLORI INFECTION ALTER THE DIURNAL RHYTHM OF THE GASTRIC CYTOPROTECTIVE TREFOIL PROTEIN TFF2

AUTHOR(S)
Johns, C. E.; Newton, J. L.; Westley, B. R.; May, F. E. B.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA23
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This article focuses on a study which found that ageing and H pylori infection alter the diurnal rhythm of the gastric cytoprotective trefoil protein TFF2. TFF2 is a small cytoprotective protein synthesised by the gastric and duodenal mucosa. The concentration of TFF2 secreted into gastric juice has a circodian rhythm in young adults. The risk of peptic ulcer disease increases with age. It was found H pylori infection reduces the fasted concentration of TFF2 in gastric juice. This may contribute to the injurious effect of H pylori on the gastric mucosa.
ACCESSION #
13218902

 

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