Johns, C. E.; Newton, J. L.; Westley, B. R.; May, F. E. B.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA23
Academic Journal
This article focuses on a study which found that ageing and H pylori infection alter the diurnal rhythm of the gastric cytoprotective trefoil protein TFF2. TFF2 is a small cytoprotective protein synthesised by the gastric and duodenal mucosa. The concentration of TFF2 secreted into gastric juice has a circodian rhythm in young adults. The risk of peptic ulcer disease increases with age. It was found H pylori infection reduces the fasted concentration of TFF2 in gastric juice. This may contribute to the injurious effect of H pylori on the gastric mucosa.


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