Johnson, A. S.; Arthur, H. M.; Burn, J.; Wilson, R. G.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA21
Academic Journal
A study has found that aspirin induces COX-2 independent endothelial cell apoptosis facilitating angiogenesis arrest, an important discovery for bowel cancer prevention. It was found that both aspirin and celecoxib caused dose dependent reduction in cell viability, proliferation and angiogenesis. Celecoxib produced these effects at levels in excess of normal serum levels when it is no longer COX-2 selective. Aspirin induces apoptosis via a COX-2 independent mechanism which may facilitate angiogenesis arrest and play a critical role in limiting tumour growth.


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