TITLE

THE PROGNOSTIC SIGNIFICANCE OF K-RAS, P53, AND APC IN COLORECTAL ADENOCARCINOMA

AUTHOR(S)
Conlin, A.; Smith, G.; Carey, F. A.; Wolf, C. R.; Steele, R. J. C.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA21
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This article focuses on the prognostic significance of Kirsten-ras, p53 and adenomatous polyposis coli (APC) in colorectal adenocarcinoma. It has been proposed that accumulation of mutations in several genes contributes to colorectal carcinogenesis and that some of these events adversely affect prognosis. This study characterised a large panel of colorectal adenocarcinomas for mutations in K-ras, p53 and APC and correlated these data with overall and disease specific survival.
ACCESSION #
13218895

 

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