Donnelly, E. T.; Bardwel, H.; Thomas, G. A.; Williams, E. D.; Hoper, M.; Crowe, P.; McCluggage, W. G.; Stevenson, M. I.; Phillips, D. H.; Hewer, A.; Osborne, M.; Campbell, F. C.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA21
Academic Journal
This article analyses colonic crypt stem cell mutation indices (CCSCMI) in a predictive risk assessment model for diet related chemicals. Humans are exposed to mixtures of harmful chemicals from diet and lifestyle but cancer risk assessment is hampered by the lack of a mechanistically based predictive model. This study test the hypothesis that CCSCMI may provide the scientific basis for a risk assessment model that is predictive of colonic tumour formation. It is found that CCSCMI induced by diet related chemicals are predictive of later colonic tumour formation and may provide the scientific basis for a risk assessment model.


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