Leslie, A.; Stewart, A.; Baty, D. U.; Pratt, N. R.; Steele, R. J. C.; Carey, F. A.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA20
Academic Journal
This article focuses on chromosomal changes in colorectal adenomas and its relation to gene mutation and clinical utility as a marker of synchronous neoplasia. APC, K-ras and p53 mutations and chromosomal change were analysed by comparative genomic hybridisation in 79 colorectal adenomas. APC and K-ras mutations were seen at a similar frequency to that observed in cancer. The study shows that specific chromosomal amplification and deletion interact in complex ways in colorectal adenomas and carcinomas. Some of the changes show great promise of clinical utility.


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