Preston, S. L.; Oukrif, D.; Kyriakides, A.; Elia, G.; Novelli, M.; Direkze, N. C.; Talbot, C.; Wright, N. A.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA20
Academic Journal
A study has found that flat adenomas in the colon originate in monocryptal adenomas and clonally expand by superficial budding without significant "top down" spread. Controversy exists concerning the mode of expansion of colorectal adenomas. The Vogeistein group champion the "top down" theory — lesions arise and grow across the mucosal surface and down into the crypts, whereas other group propose bottom up spread. Top down spread is said to be the mode of expansion of flat adenomas. It was found that flat adenomas of all sizes, while spreading predominantly in the superficial part of the mucosa, all contain dysplostic crypts which reach the muscularis mucosa.


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