TITLE

THE PRESENCE OF FAT COUNTERACTS THE ABILITY OF VITAMIN C TO PREVENT ACID N-NITROSATION

AUTHOR(S)
Paterson, S.; Iijimo, K.; Preston, T.; Scobie, G.; McColl, K. E. L.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA20
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A study has found that the presence of fat counteracts the ability of vitamin C to prevent acid N-nitrosation. Nitrite is a pre-carcinogen as it can be converted to nitrosative species and N-nitroso compounds by acidification in the presence of thiocyanate. The optimum site of acid nitrosation is the gastro-oesophageal junction where nitrite and thiocyanate secreted in saliva first encounter acidic gastric pH. The most important factor preventing this nitrosative chemistry is vitamin C, which converts the nitrosating species to nitric oxide.
ACCESSION #
13218890

 

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