TITLE

HGF/MET INCREASES THE ANCHORAGE INDEPENDENT GROWTH OF OESOPHAGEAL ADENOCARCINOMA CELLS

AUTHOR(S)
Anderson, M. R.; Campbell, M.; Jankowski, J. A. Z.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA19
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
According to a study hepatocyte growth factor (HGF) receptor MET increases the anchorage independent growth of oesophageal adenocarcinoma cells. Oesophageal adenocarcinoma develops along the Barrett's metaplasia-dysplasio-adenocarcinoma sequence. The HGF receptor MET, shows increased expression along this sequence and patients with cancers that overexpress MET exhibit poorer short term survival. It is known that MET activation downregulates the cell adhesion molecule, E-Cadherin. This article investigates a link between MET activation and cell survival and growth.
ACCESSION #
13218889

 

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