TITLE

HIGH DENSITY OLIGONUCLEOTIDE ARRAYS DEMONSTRATE DIFFERENTIAL GENE EXPRESSION IN COLON CANCER CELLS FOLLOWING COX-2 INHIBITION

AUTHOR(S)
Byrne, S. M.; Doherty, G. A.; Scully, G. M.; Murray, F. E.; Fitzgerald, D. J.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA18
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
According to a study high density oligonucleotide arrays demonstrate differential gene expression in colon cancer cells following COX-2 inhibition. COX-2 plays a crucial role in colorectal carcinogenesis and selective COX-2 inhibitors have been shown to have antineoplastic effects in vitro and in vivo. The precise mechanisms underlying these effects has yet to be established. 110 genes were identified as being consistently differentially expressed in response to COX-2 inhibition. Ontology analysis revealed that many of these genes are involved in regulation of cell proliferation, signal transduction and apoptosis.
ACCESSION #
13218884

 

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