TITLE

THE EFFECT OF METHOXAMINE ON ANAL SPHINCTER TONE IN VITRO: A POTENTIAL TREATMENT FOR INCONTINENCE

AUTHOR(S)
Nisar, P. J.; Acheson, A. G.; Gruss, H. J.; Schdefield, J. H.; Wilson, V. G.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA18
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This article examines the effects of racemic methoxamine, L-erythro methoxamine and phenylephrine on sheep internal anal sphincter (lAS) tone in vitro. Pharmacological manipulation of the anal sphincter with α-adrenoceptor agonists may improve function in patients with passive faecal incontinence. Topical phenylephrine causes a significant rise in resting anal pressure in incontinent subjects, but at high concentrations can cause side effects. Using a validated model, strips of sheep IAS were suspended in isolated organ baths.
ACCESSION #
13218881

 

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