TITLE

TRANSCRIPTOME ANALYSIS OF THE HUMAN COLON CANCER CELL LINE CoCo2 FOLLOWING EXPOSURE TO SULFORAPHANE REVEALS P21 AND KLF4 MEDIATE CELL CYCLE ARREST AND DIFFERENTIATION

AUTHOR(S)
Traka, M.; Mithen, R.; Fry, J.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA16
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Sulforaphane, obtained from the consumption of broccoli, has been implicated as a potentially important dietary anticarcinogen. It has been reported to be a potent inducer of phase II detoxification enzymes, and to induce expression of genes associated with cell cycle arrest and apoptosis in both cell cultures and animal models. To further investigate the bioactivity of sulforaphane, particularly with regard to cell cycle regulation, authors quantified gene expression in cancer cell line CaCo-2 cells, following exposure to a range of physiologically appropriate concentrations of sulforaphane via affymetrix oligonucleotide arrays and real time polymerase chain reaction.
ACCESSION #
13218876

 

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