Garle, M. J.; Middleton, B.; Hawkey, C.J.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA16
Academic Journal
Sulindac sulphide (SS), a cancer preventative metabolite of sulindac, inhibits mitochondrial oxidation of a range of metabolic substrates including fatty acids and intermediates of the tricarboxylic acid cycle. Metabolic inhibition may contribute to the anticancer action of SS; so authors have extended this work to see if other NSAIDS inhibit oxidative metabolism in liver mitochondria. SS and close structural analogues were the most potent inhibitors of mitochondrial glutamate oxidation. Inhibition of mitochondrial respiration may contribute to the anti-cancer action of these compounds by causing accumulation of short chain fatty acids that promote differentiation.


Related Articles

  • Does Aspirin Help Prevent Cancer? Wright, Karen // Discover;Jun2001, Vol. 22 Issue 6, p29 

    Provides insights on the role of nonsteroidal anti-inflammatory drugs (NSAID) in the prevention of cancer. Slowing of the growth of tumors; Side effects and toxicity of NSAID.

  • Synergistic Effect of Sulindac and Simvastatin on Apoptosis in Lung Cancer A549 Cells through AKT-Dependent Downregulation of Survivin. Young-Suk Kim; Chang-Hwan Seol; Su-Jin Oh; Ki-Eun Hwang; Hwi-Jung Kim; Eun-Taik Jeong; Hak-Ryul Kim // Cancer Research & Treatment;Jan2015, Vol. 47 Issue 1, p90 

    Purpose: Non-steroidal anti-inflammatory drugs (NSAIDs) and statins are potential chemopreventive or chemotherapeutic agents. The mechanism underlying the deregulation of survivin by NSAIDs and statins in human non-small cell lung cancer cells has not been elucidated. In this study, we...

  • Sulindac treatment alters collagen and matrilysin expression in adenomas of ApcMin/+ mice. Hector Guillen-Ahlers; Steven A. Buechler; Mark A. Suckow; Francis J. Castellino; Victoria A. Ploplis // Carcinogenesis;Jul2008, Vol. 29 Issue 7, p1421 

    Non-steroidal anti-inflammatory drugs (NSAIDs) have shown potential as chemopreventive agents against cancer formation, especially colorectal cancers. However, the mechanisms by which these drugs act are not fully understood. In this study, ApcMin/+ mice, a genetic model of human familial...

  • Aspirin can protect against skin cancer.  // Asian Pacific Post;6/7/2012, p13 

    This article reports on a study which revealed the role of nonsteroidal anti-inflammatory drugs (NSAIDS) in skin cancer protection.

  • Aspirin shown to reduce risk of pancreatic cancer. Gottlieb, Scott // BMJ: British Medical Journal (International Edition);8/17/2002, Vol. 325 Issue 7360, p356 

    Reports findings that aspirin helps prevent cancer of the pancreas. Results from a study of postmenopausal women, including that the risk for pancreatic cancer in women who took aspirin or products containing aspirin was lower than for those women who did not; Evidence in other studies that the...

  • Risk breaker? Munson, Marty; Higbee, Beth // Prevention;Jul96, Vol. 48 Issue 7, p19 

    Cites a report published in the March 1996 issue of `Epidemiology' periodical stating that aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) can prevent risks of breast cancer in women. List of NSAIDs that may be used to prevent the disease; Study leader Randall Harris'...

  • Anandamide metabolism by fatty acid amide hydrolase in intact C6 glioma cells. Increased sensitivity to inhibition by ibuprofen and flurbiprofen upon reduction of extra- but not intracellular pH. Holt, Sandra; Fowler, Christopher J. // Naunyn-Schmiedeberg's Archives of Pharmacology;Mar2003, Vol. 367 Issue 3, p237 

    The metabolism of anandamide by fatty acid amidohydrolase (FAAH) at different intra- and extracellular pH values has been investigated in intact C6 rat glioma cells. The cellular uptake of anandamide at 37°C was found to decrease by 28% when the extracellular pH (pHe) was reduced from pH 7.4...

  • Polymorphic human prostaglandin H synthase-2 proteins and their interactions with cyclooxygenase substrates and inhibitors. Liu, W; Poole, E M; Ulrich, C M; Kulmacz, R J // Pharmacogenomics Journal;Oct2011, Vol. 11 Issue 5, p337 

    The cyclooxygenase (COX) activity of prostaglandin H synthase-2 (PGHS-2) is implicated in colorectal cancer and is targeted by nonsteroidal anti-inflammatory drugs (NSAIDs) and dietary n−3 fatty acids. We used purified, recombinant proteins to evaluate the functional impacts of the R228H,...

  • Reduced Expression of 15-Lipoxygenase 2 in Human Head and Neck Carcinomas. Dian Wang; Shaoying Chen; Ying Feng; Qiuhui Yang; Campbell, Bruce H.; Xin Tang; Campbell, William B. // Tumor Biology;2006, Vol. 27 Issue 5, p261 

    Nonsteroidal anti-inflammatory drugs (NSAIDs) have demonstrated cancer chemoprevention effects associated with their ability to modulate polyunsaturated fatty acid metabolism. In the present study, we report a significant reduction of 15-lipoxygenase 2 (15-LOX-2) in seven carcinoma cell lines of...


Read the Article


Sign out of this library

Other Topics