Garle, M. J.; Middleton, B.; Hawkey, C.J.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA16
Academic Journal
Sulindac sulphide (SS), a cancer preventative metabolite of sulindac, inhibits mitochondrial oxidation of a range of metabolic substrates including fatty acids and intermediates of the tricarboxylic acid cycle. Metabolic inhibition may contribute to the anticancer action of SS; so authors have extended this work to see if other NSAIDS inhibit oxidative metabolism in liver mitochondria. SS and close structural analogues were the most potent inhibitors of mitochondrial glutamate oxidation. Inhibition of mitochondrial respiration may contribute to the anti-cancer action of these compounds by causing accumulation of short chain fatty acids that promote differentiation.


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