Shek, F. W.; Li, K. F.; Mann, J.; Williams, E. J.; Iredale, J. P.; Beynon, R. C.; Fine, D. R.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA16
Academic Journal
Pancreatic stellate cells (PSC) play an important role in the production of extracellular matrix in pancreatic fibrosis. In contrast to TGF-β1, TGF-β3 appears to have anti-scanning properties in cutaneous wound healing. The study examined the role of TGF-β3 in the deposition of collagen and the balance of the metalloproteinases (MMP) and tissue inhibitors of metalloproteinases in PSC. The results suggest that TGF-β3 possesses anti-fibrotic properties in PSC by reducing collagen secretion; and by decreasing this potent MMP inhibitor, TIMP-1 mRNA expression. This is the first description of anti-fibrotic action by TGF-β3 in a non-cutaneous system.


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