TITLE

TRANSFORMING GROWTH FACTOR-BETA3 (TGF-β3) EXPRESSES ANTI-FIBROTIC PROPERTIES IN PANCREATIC STELLATE CELLS

AUTHOR(S)
Shek, F. W.; Li, K. F.; Mann, J.; Williams, E. J.; Iredale, J. P.; Beynon, R. C.; Fine, D. R.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA16
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Pancreatic stellate cells (PSC) play an important role in the production of extracellular matrix in pancreatic fibrosis. In contrast to TGF-β1, TGF-β3 appears to have anti-scanning properties in cutaneous wound healing. The study examined the role of TGF-β3 in the deposition of collagen and the balance of the metalloproteinases (MMP) and tissue inhibitors of metalloproteinases in PSC. The results suggest that TGF-β3 possesses anti-fibrotic properties in PSC by reducing collagen secretion; and by decreasing this potent MMP inhibitor, TIMP-1 mRNA expression. This is the first description of anti-fibrotic action by TGF-β3 in a non-cutaneous system.
ACCESSION #
13218873

 

Related Articles

  • β-catenin and transforming growth factor β have distinct roles regulating fibroblast cell motility and the induction of collagen lattice contraction. Poon, Raymond; Nik, Saeid Amini; Ahn, Jessica; Slade, Laura; Alman, Benjamin A. // BMC Cell Biology;2009, Vol. 10, Special section p1 

    Background: β-catenin and transforming growth factor β signaling are activated in fibroblasts during wound healing. Both signaling pathways positively regulate fibroblast proliferation during this reparative process, and the effect of transforming growth factor β is partially mediated...

  • E-Cadherin Expression Is Regulated by miR-192/215 by a Mechanism That Is Independent of the Profibrotic Effects of Transforming Growth Factor-β. Wang, Bo; Herman-Edelstein, Michal; Koh, Philip; Burns, Wendy; Jandeleit-Dahm, Karin; Watson, Anna; Saleem, Moin; Goodall, Gregory J.; Twigg, Stephen M.; Cooper, Mark E.; Kantharidis, Phillip // Diabetes;Jul2010, Vol. 59 Issue 7, p1794 

    OBJECTIVE--Increased deposition of extracellular matrix (ECM) within the kidney is driven by profibrotic mediators including transforming growth factor-β (TGF-β) and connective tissue growth factor (CTGF). We investigated whether some of their effects may be mediated through changes in...

  • Expression of Type VI Collagen mRNA During Wound Healing. Oono, Takashi; Specks, Ulrich; Eckes, Beate; Majewski, Slawomir; Hunzelmann, Nicolas; Timpl, Rupert; Krieg, Thomas // Journal of Investigative Dermatology;Mar1993, Vol. 100 Issue 3, p329 

    During the highly regulated process of wound healing the expression of the interstitial collagens I and III is increased in a time-dependent fashion. Although ultrastructural and in vitro studies suggest a physiologic role of collagen VI in the organization of extracellular matrix...

  • Participation of miR-200a in TGF-β1-mediated hepatic stellate cell activation. Sun, Xu; He, Yong; Ma, Tao-Tao; Huang, Cheng; Zhang, Lei; Li, Jun // Molecular & Cellular Biochemistry;Mar2014, Vol. 388 Issue 1/2, p11 

    Hepatic stellate cell (HSC) activation is a pivotal event in the initiation and progression of hepatic fibrosis since it mediates transforming growth factor beta 1 (TGF-β1)-driven extracellular matrix (ECM) deposition. MicroRNAs (miRNAs), small non-coding RNAs modulating messenger RNA (mRNA)...

  • Loss of matrix metalloproteinase-2 amplifies murine toxin-induced liver fibrosis by upregulating collagen I expression. Radbill, Brian; Gupta, Ritu; Ramirez, Maria; DiFeo, Analisa; Martignetti, John; Alvarez, Carlos; Friedman, Scott; Narla, Goutham; Vrabie, Raluca; Bowles, Robert; Saiman, Yedidya; Bansal, Meena; Radbill, Brian D; Ramirez, Maria Celeste M; Martignetti, John A; Alvarez, Carlos E; Friedman, Scott L; Bansal, Meena B // Digestive Diseases & Sciences;Feb2011, Vol. 56 Issue 2, p406 

    Background and Aims: Matrix metalloproteinase-2 (MMP-2), a type IV collagenase secreted by activated hepatic stellate cells (HSCs), is upregulated in chronic liver disease and is considered a profibrotic mediator due to its proliferative effect on cultured HSCs and ability to...

  • Transforming Growth Factor-β1 and Basic Fibroblast Growth Factor Modulate Osteocalcin and Osteonectin/SPARC Syntheses in Vitamin-D-Activated Pulp Cells. Shiba, H.; Uchida, Y.; Kamihagi, K.; Sakata, M.; Fujita, T.; Nakamura, S.; Takemoto, T.; Kato, Y.; Kurihara, H. // Journal of Dental Research;Jul2001, Vol. 80 Issue 7, p1653 

    Vitamin D deficiency elicits hypocalcified dentin. However, little is known about the action of vitamin D on the syntheses of dentin matrix proteins. In this study, we examined the effects of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] on the expressions of osteocalcin and osteonectin/secreted...

  • Age-Dependent Expression of Fibrosis-Related Genes and Collagen Deposition in Rat Kidney Cortex. Gagliano, Nicoletta; Arosio, Beatrice // Journals of Gerontology Series A: Biological Sciences & Medical ;Aug2000, Vol. 55A Issue 8, pB365 

    Presents a study which characterized the age-dependent course of the abundance of transcripts for type I and type III collagen and for transforming growth factor (TGF)-beta1 and TGF-beta3. Correlation of the messenger RNA expression specific for these collagens with the amount of relative...

  • A role for the collagen I/III and MMP-1/-13 genes in primary inguinal hernia? Rosch, Raphael; Klinge, Uwe; Zhongyi Si; Junge, Karsten; Klosterhalfen, Bernd; Schumpelick, Volker // BMC Medical Genetics;2002, Vol. 3, p1 

    Background: Abnormal collagen metabolism is thought to play an important role in the development of primary inguinal hernia. This is underlined by detection of altered collagen metabolism and structural changes of the tissue in patients with primary inguinal hernia. However, it is still unknown...

  • PPAR gamma inhibits growth of rat hepatic stellate cells and TGF beta-induced connective tissue growth factor expression. Kai Sun; Qian Wang; Xiao-hui Huang // Acta Pharmacologica Sinica;Jun2006, Vol. 27 Issue 6, p715 

    Aim: To investigate the effect of peroxisome proliferator-activated receptor gamma (PPARγ) activation on the growth of rat hepatic stellate cells (HSC) and transforming growth factor beta (TGF-β)-induced connective tissue growth factor (CTGF) expression. Methods: After being treated with...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics