TITLE

EXPRESSION PATTERNS OF PROTEINS INVOLVED IN DNA DOUBLE STRAND BREAK REPAIR IN GASTRIC CANCER

AUTHOR(S)
Grabsch, H.; Rotimi, O.; Agarwal, M.; Mueller, W.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA15
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The mammalian genome is at constant risk of mutation as a result of continually being exposed to DNA damaging agents. One particularly harmful form of DNA damage is the double strand break (DSB). DSBs repair depends on Iwo distinct mechanisms:homologous recombination (HR) and nonhomologous end-joining. Inaccurate DSB repair can result in chromosomal instability and neoplastic transformation. At present, the involvement of DSB repair pathways has not been investigated in gastric cancer (GC) at all. This is the first study investigating the expression of DNA DSB repair related proteins in GC.
ACCESSION #
13218871

 

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