TITLE

REGULATION OF PLASMINOGEN ACTIVATOR INHIBITOR 2 (PAI-2) BY HELICOBACTER PYLORI: ROLE IN INVASION AND IN APOPTOSIS

AUTHOR(S)
Varro, A.; Noble, P. J. M.; Pritchard, D. M.; Kennedy, S.; Dimaline, R.; Hart, C. A.; Dockray, G. J.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA15
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Gastric adenocarcinoma is linked to infection with Helicobacter (H) pylori. Host, pathogen, and environmental factors probably determine whether infection progresses to cancer, but specific targets influencing the progression are unclear. Previous studies indicate that the gut hormone gastrin, which is increased in H. pylori infection, stimulates gastric expression of plasminogen activator inhibitor (PAI)-2. The latter inhibits urokinase plasminogen activator and is increased in gastric adenocarcinoma. Authors have examined H. pylori induction of PAI-2 and the effects on cell invasion and apoptosis.
ACCESSION #
13218870

 

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